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Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis.

Oral diseases - 1 Apr 2019

Yu Miao, Wong Sing-Wai, Han Dong, Cai Tao

Abstract excerpt

Tooth agenesis (TA) is one of the most common developmental anomalies that affects the number of teeth. An extensive analysis of publicly accessible databases revealed 15 causative genes responsible for nonsyndromic TA, along with their signaling pathways in Wnt/β-catenin, TGF-β/BMP, and Eda/Edar/NF-κB. However, genotype-phenotype correlation analysis showed that most of the causal genes are also responsible for...

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Anodontia
Axin Protein
Ectodysplasins
Edar Receptor
Latent TGF-beta Binding Proteins
Low Density Lipoprotein Receptor-Related Protein-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MSX1 Transcription Factor

PAX9 Transcription Factor

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Identifiers

PMID: 29969831
DOI: 10.1111/odi.12931
PMCID: PMC6318069

Genes

AXIN2
EDA
LRP6
MSX1
PAX9
BMP4
DKK1
EDAR
EDARADD
GREM2
KREMEN1
LTBP3
SMOC2

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