Article
Association of polymorphisms in the erythropoietin gene with diabetic retinopathy: a case-control study and systematic review with meta-analysis.
BMC ophthalmology - 4 Jun 2022
Sesti Luís Fernando Castagnino, Sbruzzi Renan Cesar, Polina Evelise Regina, Dos Santos Soares Douglas, Crispim Daisy, Canani Luís Henrique, Dos Santos Kátia Gonçalves
Abstract excerpt
BACKGROUND: Diabetic retinopathy (DR) is characterized by ischemia, hypoxia, and angiogenesis. Erythropoietin (EPO), an angiogenic hormone, is upregulated in DR, and the association of EPO genetic variants with DR is still uncertain, as conflicting results have been reported. Therefore, we performed a case-control study followed by a meta-analysis to investigate whether the rs1617640, rs507392, and rs551238...
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