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Article

Partial resection offers an overall survival benefit over biopsy in MGMT-unmethylated IDH-wildtype glioblastoma patients.

Surgical oncology - 1 Dec 2020

Hallaert Giorgio, Pinson Harry, Vanhauwaert Dimitri, Van den Broecke Caroline, Van Roost Dirk, Boterberg Tom, Kalala Jean-Pierre

Abstract excerpt

Background Isocitrate dehydrogenase (IDH)-wildtype glioblastoma patients with O6-methylguanine-DNA-methyltransferase (MGMT)-unmethylated tumors have the worst outcome of all glioblastoma patients. The overall survival (OS) benefit of partial resection of glioblastoma compared to biopsy only remains controversial specifically in relation to molecular factors. In this report, we analyzed the effect of incomplete...

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Biopsy
Chemoradiotherapy
DNA Modification Methylases
DNA Repair Enzymes
Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Neurosurgical Procedures

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PMID: 33152608
DOI: 10.1016/j.suronc.2020.10.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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