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Article

Correlation between single-nucleotide polymorphisms and statin-induced myopathy: a mixed-effects model meta-analysis.

European journal of clinical pharmacology - 1 Apr 2021

Xiang Qian, Zhang Xiao-Dan, Mu Guang-Yan, Wang Zhe, Liu Zhi-Yan, Xie Qiu-Fen, Hu Kun, Zhang Zhuo, Ma Ling-Yue, Jiang Jie, Cui Yi-Min

Abstract excerpt

PURPOSE: A meta-analysis was performed to evaluate the correlation between single-nucleotide polymorphisms (SNPs) and risk of statin-induced myopathy (SIM). METHODS: We retrieved the studies published on SIM until April 2019 from the PubMed, Embase, and Cochrane Library databases. We collected data from 32 studies that analyzed 10 SNPs in five genes and included 21,692 individuals and nine statins. RESULTS: The...

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PMID: 33150478
DOI: 10.1007/s00228-020-03029-1

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