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Cytoskeleton-based forecasting of stem cell lineage fates

18 Dec 2009

Abstract excerpt

Stem cells that adopt distinct lineages cannot be distinguished based on traditional cell shape. This study reports that higher-order variations in cell shape and cytoskeletal organization that occur within hours of stimulation forecast the lineage commitment fates of human mesenchymal stem cells (hMSCs). The unique approach captures numerous early (24 h), quantitative features of actin fluororeporter shapes,...

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PMID: 20080726
DOI: 10.1073/pnas.0909597107

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