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Article

Cardiac pathology in mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling.

Journal of inherited metabolic disease - 1 May 2021

Gonzalez Esteban Alberto, Tobar Leitão Santiago Alonso, Soares Douglas Dos Santos, Tavares Angela Maria Vicente, Giugliani Roberto, Baldo Guilherme, Matte Ursula

Abstract excerpt

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder caused by mutations in the IDUA gene, that codifies the alpha-L-iduronidase enzyme, which deficiency leads to storage of glycosaminoglycans, with multiple clinical manifestations. One of the leading causes of death in MPS I patients are cardiac complications such as cardiac valve thickening, conduction abnormalities, myocardial dysfunction, and...

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Source

Identifiers

PMID: 33145772
DOI: 10.1002/jimd.12327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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