Article
Mutations in PIH proteins MOT48, TWI1 and PF13 define common and unique steps for preassembly of each, different ciliary dynein.
PLoS genetics - 1 Nov 2020
Yamamoto Ryosuke, Yanagi Shiho, Nagao Masahito, Yamasaki Yuya, Tanaka Yui, Sale Winfield S, Yagi Toshiki, Kon Takahide
Abstract excerpt
Ciliary dyneins are preassembled in the cytoplasm before being transported into cilia, and a family of proteins containing the PIH1 domain, PIH proteins, are involved in the assembly process. However, the functional differences and relationships between members of this family of proteins remain largely unknown. Using Chlamydomonas reinhardtii as a model, we isolated and characterized two novel Chlamydomonas PIH...
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