Article
The ciliary inner dynein arm, I1 dynein, is assembled in the cytoplasm and transported by IFT before axonemal docking.
Cytoskeleton (Hoboken, N.J.) - 1 Oct 2014
Viswanadha Rasagnya, Hunter Emily L, Yamamoto Ryosuke, Wirschell Maureen, Alford Lea M, Dutcher Susan K, Sale Winfield S
Abstract excerpt
To determine mechanisms of assembly of ciliary dyneins, we focused on the Chlamydomonas inner dynein arm, I1 dynein, also known as dynein f. I1 dynein assembles in the cytoplasm as a 20S complex similar to the 20S I1 dynein complex isolated from the axoneme. The intermediate chain subunit, IC140 (IDA7), and heavy chains (IDA1, IDA2) are required for 20S I1 dynein preassembly in the cytoplasm. Unlike I1 dynein...
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