Article
Hemeprotein Tpx1 interacts with cell-surface heme transporter Str3 in Schizosaccharomyces pombe.
Molecular microbiology - 1 Apr 2021
Normant Vincent, Brault Ariane, Avino Mariano, Mourer Thierry, Vahsen Tobias, Beaudoin Jude, Labbé Simon
Abstract excerpt
Str3 is a transmembrane protein that mediates low-affinity heme uptake in Schizosaccharomyces pombe. Under iron-limiting conditions, Str3 remains at the cell surface in the presence of increasing hemin concentrations. Using a proximity-dependent biotinylation approach coupled to mass spectrometry and coimmunoprecipitation assays, we report that the peroxiredoxin Tpx1 is a binding partner of Str3. Under...
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