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Article

Parallel evolution in the emergence of highly pathogenic avian influenza A viruses.

Nature communications - 2 Nov 2020

Escalera-Zamudio Marina, Golden Michael, Gutiérrez Bernardo, Thézé Julien, Keown Jeremy Russell, Carrique Loic, Bowden Thomas A, Pybus Oliver G

Abstract excerpt

Parallel molecular evolution and adaptation are important phenomena commonly observed in viruses. Here, we exploit parallel molecular evolution to understand virulence evolution in avian influenza viruses (AIV). Highly-pathogenic AIVs evolve independently from low-pathogenic ancestors via acquisition of polybasic cleavage sites. Why some AIV lineages but not others evolve in this way is unknown. We hypothesise...

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Identifiers

PMID: 33139731
DOI: 10.1038/s41467-020-19364-x
PMCID: PMC7608645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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