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Article

Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis.

Cell reports. Medicine - 17 Oct 2023

Liang Mengmeng, Wang Ke, Wei Xiaoyu, Gong Xiaoshan, Tang Hao, Xue Hao, Wang Jing, Yin Pengbin, Zhang Licheng, Ma Zaisong, Dou Ce, Dong Shiwu, Xu Jianzhong, Luo Fei, Ma Qinyu

Abstract excerpt

The interleukin 6 (IL6) signaling pathway plays pleiotropic roles in regulating the inflammatory milieu that contributes to arthritis development. Here, we show that activation of IL6 trans-signaling induces phenotypic transitions in tissue-resident cells toward an inflammatory state. The establishment of arthritis increases the serum number of extracellular vesicles (EVs), while these EVs express more IL6 signal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37852176
DOI: 10.1016/j.xcrm.2023.101228
PMCID: PMC10591050

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