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Article

Regulation of IL12B Expression in Human Macrophages by TALEN-mediated Epigenome Editing.

Current medical science - 1 Oct 2020

Chen Meng, Zhu Hua, Mao Yu-Juan, Cao Nan, Yu Ya-Li, Li Lian-Yun, Zhao Qiu, Wu Min, Ye Mei

Abstract excerpt

Although the exact etiology of inflammatory bowel disease (IBD) remains unclear, exaggerated immune response in genetically predisposed individuals has been reported. Th1 and Th17 cells mediate IBD development. Macrophages produce IL-12 and IL-23 that share p40 subunit encoded by IL12B gene as heteromer partner to drive Th1 and Th17 differentiation. The available animal and human data strongly support the...

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Share to DNA (Cytosine-5-)-Methyltransferases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33123904
DOI: 10.1007/s11596-020-2249-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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