Mutational Landscape and Tumor Burden Assessed by Cell-free DNA in Diffuse Large B-Cell Lymphoma in a Population-Based Study.

doi:10.1158/1078-0432.CCR-20-2558

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Article

Mutational Landscape and Tumor Burden Assessed by Cell-free DNA in Diffuse Large B-Cell Lymphoma in a Population-Based Study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2021

Rivas-Delgado Alfredo, Nadeu Ferran, Enjuanes Anna, Casanueva-Eliceiry Sebastián, Mozas Pablo, Magnano Laura, Castrejón de Anta Natalia, Rovira Jordina, Dlouhy Ivan, Martín Silvia, Osuna Miguel, Rodríguez Sonia, Simó Marc, Pinyol Magda, Baumann Tycho, Beà Silvia, Balagué Olga, Delgado Julio, Villamor Neus, Setoain Xavier, Campo Elías, Giné Eva, López-Guillermo Armando

Abstract excerpt

PURPOSE: We analyzed the utility of cell-free DNA (cfDNA) in a prospective population-based cohort to determine the mutational profile, assess tumor burden, and estimate its impact in response rate and outcome in patients with diffuse large B-cell lymphoma (DLBCL). EXPERIMENTAL DESIGN: A total of 100 patients were diagnosed with DLBCL during the study period. Mutational status of 112 genes was studied in cfDNA by...

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PMID: 33122345
DOI: 10.1158/1078-0432.CCR-20-2558

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