Article
Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness.
Virology - 2 Jan 2021
Scroggs Stacey L P, Gass Jordan T, Chinnasamy Ramesh, Widen Steven G, Azar Sasha R, Rossi Shannan L, Arterburn Jeffrey B, Vasilakis Nikos, Hanley Kathryn A
Abstract excerpt
Drugs against flaviviruses such as dengue (DENV) and Zika (ZIKV) virus are urgently needed. We previously demonstrated that three fluoroquinolones, ciprofloxacin, enoxacin, and difloxacin, suppress replication of six flaviviruses. To investigate the barrier to resistance and mechanism(s) of action of these drugs, DENV-4 was passaged in triplicate in HEK-293 cells in the presence or absence of each drug....
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