Article
APC mutations in human colon lead to decreased neuroendocrine maturation of ALDH+ stem cells that alters GLP-2 and SST feedback signaling: Clue to a link between WNT and retinoic acid signalling in colon cancer development.
PloS one - 1 Jan 2020
Zhang Tao, Ahn Koree, Emerick Brooks, Modarai Shirin R, Opdenaker Lynn M, Palazzo Juan, Schleiniger Gilberto, Fields Jeremy Z, Boman Bruce M
Abstract excerpt
APC mutations drive human colorectal cancer (CRC) development. A major contributing factor is colonic stem cell (SC) overpopulation. But, the mechanism has not been fully identified. A possible mechanism is the dysregulation of neuroendocrine cell (NEC) maturation by APC mutations because SCs and NECs both reside together in the colonic crypt SC niche where SCs mature into NECs. So, we hypothesized that...
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