Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis.

Molecular diagnosis & therapy - 1 Mar 2026

Rodríguez Sánchez Diana Ivonne, Öztürk Selin Asli, Maxouri Olga, van der Mierden Stevie, Schats Winnie, Rostami Sajjad, Ursprung Stephan, Snaebjornsson Petur, Bodalal Zuhir, Beets-Tan Regina

Abstract excerpt

BACKGROUND: Activating epidermal growth factor receptor (EGFR) mutations are key drivers in non-small cell lung cancer (NSCLC) and other solid tumours, predicting responses to tyrosine kinase inhibitors (TKIs). Tumour heterogeneity alongside sampling and technical factors may contribute to discordant EGFR status across biopsies, complicating treatment decisions. However, systematic evidence on prevalence and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to EGFR gene

Share to Genetic Heterogeneity

Share to Lung Neoplasms

Share to Mutation

Share to Protein Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 41642450
DOI: 10.1007/s40291-026-00829-6
PMCID: PMC12999597

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interlesional Heterogeneity of EGFR Mutations: A Systematic Review and Meta-analysis.PMID 41642450Read ↗

EGFR mutation heterogeneity and the mixed response to EGFR tyrosine kinase inhibitors of lung adenocarcinomas.Semantic proximity Read ↗

Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing: results of the RING observational trial.Semantic proximity Read ↗

Resistance to osimertinib in advanced EGFR-mutated NSCLC: a prospective study of molecular genotyping on tissue and liquid biopsies.Semantic proximity Read ↗

Rare discrepancies in a driver gene alteration within histologically heterogeneous primary lung cancers.Semantic proximity Read ↗

Clinical characteristics and treatment outcomes of lung adenocarcinomas with discrepant EGFR mutation testing results derived from PCR-direct sequencing and real-time PCR-based assays.Semantic proximity Read ↗

A comparative study of EGFR oncogenic mutations in matching tissue and plasma samples from patients with advanced non-small cell lung carcinoma.Semantic proximity Read ↗

FACILITATE: A real-world, multicenter, prospective study investigating the utility of a rapid, fully automated real-time PCR assay versus local reference methods for detecting epidermal growth factor receptor variants in NSCLC.Semantic proximity Read ↗

Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy.Semantic proximity Read ↗

Epidermal growth factor receptor mutation analysis in tissue and plasma from the AURA3 trial: Osimertinib versus platinum-pemetrexed for T790M mutation-positive advanced non-small cell lung cancer.Semantic proximity Read ↗

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib.Semantic proximity Read ↗

Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.Semantic proximity Read ↗

Tumour Content Ratio Matters for Detecting Epidermal Growth Factor Receptor Mutation by Cobas Test in Small Biopsies; a Retrospective StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.