Article
Rapid acquisition of decreased carbapenem susceptibility in a strain of Klebsiella pneumoniae arising during meropenem therapy.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Feb 2012
Findlay J, Hamouda A, Dancer S J, Amyes S G B
Abstract excerpt
A strain of Klebsiella pneumoniae (K1) was isolated from a catheterized patient with a urinary tract infection. The patient was subsequently treated with meropenem, after which K. pneumoniae (K2) was once again isolated from the patient's urine. Susceptibility testing showed that strain K1 was fully susceptible to carbapenem antibiotics with the exception of ertapenem, to which it exhibited intermediate...
Topics
- Anti-Bacterial Agents
- Bacterial Outer Membrane Proteins
- Catheter-Related Infections
- Conjugation, Genetic
- DNA, Bacterial
- Electrophoresis, Gel, Pulsed-Field
- Ertapenem
- Gene Expression Profiling
- Gene Transfer, Horizontal
- Genotype
- Humans
- Klebsiella Infections