Article
Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma.
International journal of molecular sciences - 21 Oct 2020
Makarevic Anastasia, Rapp Carmen, Dettling Steffen, Reuss David, Jungk Christine, Abdollahi Amir, von Deimling Andreas, Unterberg Andreas, Herold-Mende Christel, Warta Rolf
Abstract excerpt
Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (n = 78) and recurrent (n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and...
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