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Article

Kisspeptin deficiency leads to abnormal adrenal glands and excess steroid hormone secretion.

Human molecular genetics - 18 Dec 2020

Berthon Annabel, Settas Nikolaos, Delaney Angela, Giannakou Andreas, Demidowich Andrew, Faucz Fabio R, Seminara Stephanie B, Chen Margaret E, Stratakis Constantine A

Abstract excerpt

Knockout mice for the kisspeptin receptor, Kiss1r (Kiss1r-/-) and its ligand kisspeptin, Kiss1 (Kiss1-/-) replicate the phenotype of isolated hypogonadotropic hypogonadism (IHH) associated with variants of these genes in humans. A recent report suggests that kisspeptin may be involved in human fetal adrenocortical development and function. Herein, we characterized the adrenal function and morphology in Kiss1-/-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33089319
DOI: 10.1093/hmg/ddaa215
PMCID: PMC7906779

Genes

CS
KISS1
IHH
KISS1R

Variants

rs201073751
rs73507527
rs141767649
rs115335009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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