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Article

Use of a carbonic anhydrase Ca17a knockout to investigate mechanisms of ion uptake in zebrafish (Danio rerio).

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Jan 2021

Zimmer Alex M, Mandic Milica, Yew Hong Meng, Kunert Emma, Pan Yihang K, Ha Jimmy, Kwong Raymond W M, Gilmour Kathleen M, Perry Steve F

Abstract excerpt

In fishes, branchial cytosolic carbonic anhydrase (CA) plays an important role in ion and acid-base regulation. The Ca17a isoform in zebrafish (Danio rerio) is expressed abundantly in Na+-absorbing/H+-secreting H+-ATPase-rich (HR) cells. The present study aimed to identify the role of Ca17a in ion and acid-base regulation across life stages using CRISPR/Cas9 gene editing. However, in preliminary experiments, we...

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Identifiers

PMID: 33085911
DOI: 10.1152/ajpregu.00215.2020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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