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Article

JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML

19 Oct 2020

Abstract excerpt

Interferon α (IFNα) is used to treat JAK2V617F-driven myeloproliferative neoplasms (MPNs) but rarely clears the disease. We investigated the IFNα mechanism of action focusing on PML, an interferon target and key senescence gene whose targeting by arsenic trioxide (ATO) drives eradication of acute promyelocytic leukemia. ATO sharply potentiated IFNα-induced growth suppression of JAK2V617F patient or mouse...

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PMID: 33075130
DOI: 10.1084/jem.20201268

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