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Article

Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults

18 Oct 2020

Abstract excerpt

Evidence from clinical trials and observational studies suggests that both progressive resistance exercise training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effects of 14 weeks of PRT + metformin (metPRT) compared to PRT with placebo (plaPRT) on muscle hypertrophy in older adults. We found that metformin blunted PRT-induced muscle...

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PMID: 33071237
DOI: 10.18632/aging.104096

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