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Article

Pro-angiogenic effects of pregnancy-specific glycoproteins in endothelial and extravillous trophoblast cells

20 Aug 2020

Abstract excerpt

We previously reported that binding to heparan sulfate (HS) is required for the ability of the placentally secreted pregnancy-specific glycoprotein 1 (PSG1) to induce endothelial tubulogenesis. PSG1 is composed of four immunoglobulin-like domains but which domains of the protein bind to HS remains unknown. To analyze the interaction of PSG1 with HS, we generated several recombinant proteins, including the...

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PMID: 33065549
DOI: 10.1530/rep-20-0169

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