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Article

Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia

24 Jun 2013

Abstract excerpt

Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to...

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PMID: 23798433
DOI: 10.1073/pnas.1303707110

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