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Article

Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage.

The Journal of antimicrobial chemotherapy - 19 Jan 2021

Shen Tianwei, Penewit Kelsi, Waalkes Adam, Xu Libin, Salipante Stephen J, Nath Abhinav, Werth Brian J

Abstract excerpt

OBJECTIVES: Tedizolid is an oxazolidinone antimicrobial with activity against Gram-positive bacteria, including MRSA. Tedizolid resistance is uncommon and tedizolid's capacity to select for cross-resistance to other antimicrobials is incompletely understood. The objective of this study was to further explore the phenotypic and genetic basis of tedizolid resistance in MRSA. METHODS: We selected for tedizolid...

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Source

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Identifiers

PMID: 33057715
DOI: 10.1093/jac/dkaa422
PMCID: PMC8600019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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