Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular basis of linezolid resistance in Finegoldia spp. from orthopedic infections.

Antimicrobial agents and chemotherapy - 1 Apr 2026

Jean-Pierre Vincent, Moulieras Mikeldi, Pantel Alix, Aujoulat Fabien, Lavigne Jean-Philippe, Boudet Agathe, Marchandin Hélène

Abstract excerpt

Finegoldia spp. are Gram-positive anaerobic cocci increasingly recognized as opportunistic pathogens, particularly in bone infections. Linezolid (LZD), an oxazolidinone with activity against anaerobes, is frequently used in orthopedic infections but is subject to various resistance mechanisms. Here, we characterized the molecular basis of LZD resistance in Finegoldia sp. isolates from three separate cases of bone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linezolid

Share to Methyltransferases

Share to Microbial Sensitivity Tests

Share to Polymorphism, Single Nucleotide

Share to Ribosomal Proteins

Share to RNA, Ribosomal, 23S

Source

Open in PubMed Open full text

Identifiers

PMID: 41746150
DOI: 10.1128/aac.01702-25
PMCID: PMC13041314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular basis of linezolid resistance in Finegoldia spp. from orthopedic infections.PMID 41746150Read ↗

ZAAPS programme results for 2016: an activity and spectrum analysis of linezolid using clinical isolates from medical centres in 42 countries.Semantic proximity Read ↗

Pan-genome analysis of the genus Finegoldia identifies two distinct clades, strain-specific heterogeneity, and putative virulence factors.Semantic proximity Read ↗

ZAAPS International Surveillance Program (2007) for linezolid resistance: results from 5591 Gram-positive clinical isolates in 23 countriesSemantic proximity Read ↗

Molecular Analysis of Linezolid-Resistant Clinical Isolates of Mycobacterium abscessusSemantic proximity Read ↗

Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance PredictionSemantic proximity Read ↗

Clinical, Bacteriological, and Genetic Characterization of Bone and Joint Infections Involving Linezolid-Resistant Staphylococcus epidermidis: a Retrospective Multicenter Study in French Reference CentersSemantic proximity Read ↗

Research progress on the oxazolidinone drug linezolid resistance.Semantic proximity Read ↗

In vivo emergence of a still uncommon resistance to fidaxomicin in the urgent antimicrobial resistance threat Clostridioides difficileSemantic proximity Read ↗

Detecting mutations that confer oxazolidinone resistance in gram-positive bacteria.Semantic proximity Read ↗

Clostridium difficile Isolates with High Linezolid MICs Harbor the Multiresistance Gene <i>cfr</i>Semantic proximity Read ↗

Characterization of Metronidazole-Resistant Giardia intestinalis Lines by Comparative Transcriptomics and ProteomicsSemantic proximity Read ↗

Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.