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Article

Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia

25 Mar 2023

Abstract excerpt

Pancreatic development requires spatially and temporally controlled expression of growth factors derived from mesenchyme. Here, we report that in mice the secreted factor Fgf9 is expressed principally by mesenchyme and then mesothelium during early development, then subsequently by both mesothelium and rare epithelial cells by E12.5 and onwards. Global knockout of the Fgf9 gene resulted in the reduction of...

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PMID: 37096042
DOI: 10.1016/j.isci.2023.106500

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