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Article

Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriers.

JCI insight - 19 Nov 2020

Peiffer Kai-Henrik, Spengler Catrina, Basic Michael, Jiang Bingfu, Kuhnhenn Lisa, Obermann Wiebke, Zahn Tobias, Glitscher Mirco, Loglio Alessandro, Facchetti Floriana, Carra Gert, Kubesch Alica, Vermehren Johannes, Knop Viola, Graf Christiana, Dietz Julia, Finkelmeier Fabian, Herrmann Eva, Trebicka Jonel, Grünweller Arnold, Zeuzem Stefan, Sarrazin Christoph, Lampertico Pietro, Hildt Eberhard

Abstract excerpt

Many mutation analyses of the HBV genome have been performed in the search for new prognostic markers. However, the Kozak sequence preceding precore was covered only infrequently in these analyses. In this study, the HBV core promoter/precore region was sequenced in serum samples from European inactive HBV carriers. Quadruple mutation GCAC1809-1812TTCT was found with a high prevalence of 42% in the Kozak sequence...

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Identifiers

PMID: 33055418
DOI: 10.1172/jci.insight.135833
PMCID: PMC7710305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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