Article
A Novel Mechanism Underlying Antiviral Activity of an Influenza Virus M2-Specific Antibody.
Journal of virology - 9 Dec 2020
Manzoor Rashid, Eguchi Nao, Yoshida Reiko, Ozaki Hiroichi, Kondoh Tatsunari, Okuya Kosuke, Miyamoto Hiroko, Takada Ayato
Abstract excerpt
Protective immunity against influenza A viruses (IAVs) generally depends on antibodies to the major envelope glycoprotein, hemagglutinin (HA), whose antigenicity is distinctive among IAV subtypes. On the other hand, the matrix 2 (M2) protein is antigenically highly conserved and has been studied as an attractive vaccine antigen to confer cross-protective immunity against multiple subtypes of IAVs. However,...
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