Article
Monoclonal antibody recognizing SLLTEVET epitope of M2 protein potently inhibited the replication of influenza A viruses in MDCK cells.
Biochemical and biophysical research communications - 17 Jul 2009
Wang Yongjin, Zhou Licheng, Shi Huiling, Xu Hongwei, Yao Hong, Xi Xu Guang, Toyoda Tetsuya, Wang Xiaoming, Wang Tianhou
Abstract excerpt
The ectodomain of influenza A virus M2 protein (M2e) is composed of 24 amino acids and induces antibodies with inhibitory effect against a broad spectrum of influenza A subtypes in vitro and in vivo. Although relatively conserved, 21 M2e variants emerged in recent influenza A strains, most of the mutations appeared in the middle part of M2e domain. In this study, we characterized the in vitro inhibition efficacy...
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