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Micro-fusion inhibition tests: quantifying antibody neutralization of virus-mediated cell–cell fusion

15 Oct 2020

Abstract excerpt

Although enveloped viruses canonically mediate particle entry through virus–cell fusion, certain viruses can spread by cell–cell fusion, brought about by receptor engagement and triggering of membrane-bound, viral-encoded fusion proteins on the surface of cells. The formation of pathogenic syncytia or multinucleated cells is seen in vivo, but their contribution to viral pathogenesis is poorly understood. For the...

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PMID: 33054904
DOI: 10.1099/jgv.0.001506

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