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Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

9 Feb 2021

Abstract excerpt

Cell entry of the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is mediated by its spike protein S. As a main antigenic determinant, S protein is in focus of various therapeutic strategies. Besides particle-cell fusion, S mediates fusion between infected and uninfected cells resulting in syncytia formation. Here, we present sensitive assay systems with a high dynamic range and high...

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PMID: 33585805
DOI: 10.1016/j.isci.2021.102170

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