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Article

Generation of Recombinant SARS‐CoV‐2 Using a Bacterial Artificial Chromosome

13 Oct 2020

Abstract excerpt

SARS-CoV-2, the causative agent of COVID-19, has been responsible for a million deaths worldwide as of September 2020. At the time of this writing, there are no available US FDA-approved therapeutics for the treatment of SARS-CoV-2 infection. Here, we describe a detailed protocol to generate recombinant (r)SARS-CoV-2 using reverse-genetics approaches based on the use of a bacterial artificial chromosome (BAC)....

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PMID: 33048448
DOI: 10.1002/cpmc.126

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