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Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome

28 Sept 2020

Abstract excerpt

The pandemic coronavirus (CoV) disease 2019 (COVID-19) caused by severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is a major threat to global human health. To date, there are no approved prophylactics or therapeutics available for COVID-19. Reverse genetics is a powerful approach to understand factors involved in viral pathogenesis, antiviral screening, and vaccine development. In this study, we describe the...

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PMID: 32978313
DOI: 10.1128/mbio.02168-20

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