Article
Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression.
Theranostics - 1 Jan 2020
Lin Ching-Chan, Huang Yu-Kai, Cho Chia-Fong, Lin Yu-Sen, Lo Chia-Chien, Kuo Ting-Ting, Tseng Guan-Chin, Cheng Wei-Chung, Chang Wei-Chao, Hsiao Tzu-Hung, Lai Liang-Chuan, Shih Jin-Yuan, Liu Yu-Huei, Chao K S Clifford, Hsu Jennifer L, Lee Pei-Chih, Sun Xian, Hung Mien-Chie, Sher Yuh-Pyng
Abstract excerpt
Rationale: Brain metastasis in patients with lung cancer is life-threatening. However, the molecular mechanism for this catastrophic disease remains elusive, and few druggable targets are available. Therefore, this study aimed to identify and characterize proteins that could be used as therapeutic targets. Methods: Proteomic analyses were conducted to identify differentially expressed membrane proteins between...
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