Article
Germline Genetic Predisposition to Hematologic Malignancy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Mar 2017
Furutani Elissa, Shimamura Akiko
Abstract excerpt
Development of hematologic malignancies is driven by mutations that may be somatic or germline. Availability of next-generation DNA sequencing technologies has facilitated the development of individualized diagnostic evaluations and tailored treatment strategies. Until now, such personalized medical approaches have largely centered on prognostic stratification and treatment strategies informed by acquired somatic...
Topics
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Hematologic Neoplasms
- High-Throughput Nucleotide Sequencing
- Humans