Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jan 2021

Sato Hiroki, Offin Michael, Kubota Daisuke, Yu Helena A, Wilhelm Clare, Toyooka Shinichi, Somwar Romel, Kris Mark G, Ladanyi Marc

Abstract excerpt

INTRODUCTION: Unlike common EGFR mutations, many less common EGFR mutations remain poorly characterized in terms of oncogenic function and drug sensitivity. Here, we characterize the subset of lung adenocarcinoma harboring EGFR L861Q through both preclinical and clinical investigations. METHODS: We reviewed clinical and genomic data from patients with EGFR-mutant lung cancer. We established cells expressing EGFR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to ErbB Receptors

Share to Lung Neoplasms

Share to Mutation

Share to Protein Kinase Inhibitors

Share to Receptor, ErbB-2

Source

Open in PubMed Open full text

Identifiers

PMID: 33038514
DOI: 10.1016/j.jtho.2020.09.019
PMCID: PMC7775889

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-Specific Role of ERBB2 in the Oncogenic Function of EGFR L861Q in EGFR-Mutant Lung Cancers.PMID 33038514Read ↗

The epidermal growth factor receptor-L861Q mutation increases kinase activity without leading to enhanced sensitivity toward epidermal growth factor receptor kinase inhibitors.Semantic proximity Read ↗

ERBB2-Activating Mutations and Co-Occurring Genomic Alterations Contribute to Disease Heterogeneity in Patients With ERBB2-Mutant Lung Cancer.Semantic proximity Read ↗

Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma.Semantic proximity Read ↗

EGFR L858M/L861Q cis Mutations Confer Selective Sensitivity to Afatinib.Semantic proximity Read ↗

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer harboring uncommon EGFR mutations: Focus on afatinibSemantic proximity Read ↗

High-Throughput Functional Evaluation of Variants of Unknown Significance in ERBB2.Semantic proximity Read ↗

Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targetingSemantic proximity Read ↗

Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib.Semantic proximity Read ↗

Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors.Semantic proximity Read ↗

Activating ERBB4 mutations in non-small cell lung cancer.Semantic proximity Read ↗

Mechanistic insights into the activation of oncogenic forms of EGF receptor.Semantic proximity Read ↗

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.