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Article

Noninvasive Detection of Urothelial Carcinoma by Cost-effective Low-coverage Whole-genome Sequencing from Urine-Exfoliated Cell DNA.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2020

Zeng Shuxiong, Ying Yidie, Xing Naidong, Wang Baiyun, Qian Ziliang, Zhou Zunlin, Zhang Zhensheng, Xu Weidong, Wang Huiqing, Dai Lihe, Gao Li, Zhou Tie, Ji Jiatao, Xu Chuanliang

Abstract excerpt

PURPOSE: Urothelial carcinoma is a malignant cancer with frequent chromosomal aberrations. Here, we investigated the application of a cost-effective, low-coverage whole-genome sequencing technology in detecting all chromosomal aberrations. EXPERIMENTAL DESIGN: Patients with urothelial carcinomas and nontumor controls were prospectively recruited in clinical trial NCT03998371. Urine-exfoliated cell DNA was...

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Identifiers

PMID: 33037018
DOI: 10.1158/1078-0432.CCR-20-0401

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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