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Article

Somatic SDHA mutations in paragangliomas in siblings: Case report of 2 cases.

Medicine - 9 Oct 2020

Huang Yen-Chun, Chang Hsiao-Huang, Chen Ming-Huang, Huang Kuo-Hung, Li Anna Fen-Yau, Lin Chien-Hsing, Shyr Yi-Ming, Fang Wen-Liang

Abstract excerpt

RATIONALE: Paragangliomas (PGLs) are rare neuroendocrine tumors that are strongly influenced by genetics, and succinate dehydrogenase-deficient PGLs appear to constitute one of the most important categories. Interestingly, somatic PGLs only possess genomic alterations involving the SDHB and SDHD subunits, and no SDHA alterations have been described. Here, we are presenting the clinical and genetic analyses of 2...

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Identifiers

PMID: 33031286
DOI: 10.1097/MD.0000000000022497
PMCID: PMC7544306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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