Article
Hereditary paragangliomas.
Advances in oto-rhino-laryngology - 1 Jan 2011
Raygada Margarita, Pasini Barbara, Stratakis Constantine A
Abstract excerpt
Paragangliomas (PGL) and pheochromocytomas (PCC) are rare, usually benign tumors that originate from the neuroendocrine tissue along the paravertebral axis. Up to 35% of these tumors may be hereditary; they are associated with germline mutations in genes encoding subunits of the succinate dehydrogenase (SDH) enzyme complex in the context of the familial PGL syndromes, PGL1, 3 and 4 caused by mutations in the...
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