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Article

Tumor and germline next generation sequencing in high grade serous cancer: experience from a large population-based testing program.

Molecular oncology - 1 Jan 2021

Care Melanie, McCuaig Jeanna, Clarke Blaise, Grenier Sylvie, Kim Raymond H, Rouzbahman Marjan, Stickle Natalie, Bernardini Marcus, Stockley Tracy L

Abstract excerpt

The aim of this study was to determine the prevalence of somatic and germline pathogenic variants (PVs) in high-grade serous cancer (HGSC) and to demonstrate the technical feasibility and effectiveness of a large-scale, population-based tumor testing program. It involved a retrospective review of genetic test results in 600 consecutive HGSC tumor samples and a subsequent comparison of germline and tumor results...

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Identifiers

PMID: 33030818
DOI: 10.1002/1878-0261.12817
PMCID: PMC7782089

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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