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The role of caspase-8 in the tumor microenvironment of ovarian cancer

7 Oct 2020

Abstract excerpt

Caspase-8 is an aspartate-specific cysteine protease, which is best known for its apoptotic functions. Caspase-8 is placed at central nodes of multiple signal pathways, regulating not only the cell cycle but also the invasive and metastatic cell behavior, the immune cell homeostasis and cytokine production, which are the two major components of the tumor microenvironment (TME). Ovarian cancer often has...

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PMID: 33026575
DOI: 10.1007/s10555-020-09935-1

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