Article
[Something new in the genetics of monogenic obesity and its insights into pathophysiology].
Medecine sciences : M/S - 1 Oct 2020
Baron Morgane, Froguel Philippe, Bonnefond Amélie
Abstract excerpt
Obesity is a complex, multifactorial disorder. About 5% of obese patients actually present with a monogenic form of obesity where only one mutation is sufficient to cause the disease. So far, the genes that have been found to be mutated in these monogenic forms play a key role in the leptin/melanocortin pathway which is mainly active in the hypothalamus and which regulates food intake and energy expenditure. Our...
Topics
- Animals
- Appetite Regulation
- Genetic Predisposition to Disease
- Humans
- Leptin
- Mutation
- Obesity
- Precision Medicine
- Pro-Opiomelanocortin
- Receptor, Melanocortin, Type 4
- Receptors, Leptin