CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.

doi:10.7554/eLife.57132

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Article

CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.

eLife - 2 Sept 2020

Xu Kui, Zhou Yanrong, Mu Yulian, Liu Zhiguo, Hou Shaohua, Xiong Yujian, Fang Liurong, Ge Changli, Wei Yinghui, Zhang Xiuling, Xu Changjiang, Che Jingjing, Fan Ziyao, Xiang Guangming, Guo Jiankang, Shang Haitao, Li Hua, Xiao Shaobo, Li Julang, Li Kui

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for known receptor proteins CD163 and pAPN and show that DKO pigs are completely resistant to genotype 2 PRRSV and...

Topics

Animals
Animals, Genetically Modified
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Body Composition
CD13 Antigens
Coronavirus
Coronavirus Infections
Disease Susceptibility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gastroenteritis, Transmissible, of Swine

Gene Knockdown Techniques

Host Microbial Interactions

Meat-Packing Industry

Phenotype

Porcine Reproductive and Respiratory Syndrome

Porcine respiratory and reproductive syndrome virus

Receptors, Cell Surface

Sus scrofa

Source

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Identifiers

PMID: 32876563
DOI: 10.7554/eLife.57132
PMCID: PMC7467724

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CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance.PMID 32876563Read ↗

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus.Semantic proximity Read ↗

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