Article
CYP24A1 expression analysis in uterine leiomyoma regarding MED12 mutation profile.
Archives of gynecology and obstetrics - 1 Mar 2021
Fazeli Elnaz, Piltan Samira, Gholami Milad, Akbari Mojdeh, Falahati Zahra, Yassaee Fakhrolmolook, Sadeghi Hossein, Mirfakhraie Reza
Abstract excerpt
INTRODUCTION: Uterine leiomyoma (ULM) is the most common gynecological tumor. Recent studies have revealed the role of hypovitaminosis D as a major risk factor in the disease development. CYP24A, a mitochondrial enzyme that catalyzes the degradation of 1,25(OH)2D3, is reported to be over-expressed in several human cancers. In this study, we aimed to investigate the expression level of CYP24A1 in leiomyoma samples...
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