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Article

<scp>C</scp> 9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits

5 Jun 2015

Abstract excerpt

OBJECTIVE: How hexanucleotide (GGGGCC) repeat expansions in C9ORF72 cause amyotrophic lateral sclerosis (ALS) remains poorly understood. Both gain- and loss-of-function mechanisms have been proposed. Evidence supporting these mechanisms in vivo is, however, incomplete. Here we determined the effect of C9orf72 loss-of-function in mice. METHODS: We generated and analyzed a conditional C9orf72 knockout mouse model....

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PMID: 26044557
DOI: 10.1002/ana.24453

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