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Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection

2 Apr 2015

Abstract excerpt

Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkinson's disease, as well as bacterial infection. Here, we explore the roles of mitochondrial autophagy (mitophagy) and the mitochondrial unfolded protein response (UPR(mt)) in the response to mitochondrial...

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PMID: 25857750
DOI: 10.1186/s12915-015-0129-1

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