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Article

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells.

Cancer research - 1 Mar 2005

Tang Weigang, Li Ying, Yu Duonan, Thomas-Tikhonenko Andrei, Spiegelman Vladimir S, Fuchs Serge Y

Abstract excerpt

beta-Transducin repeat-containing proteins (beta-TrCP) serve as substrate recognition component of E3 ubiquitin ligases that control stability of important regulators of cell cycle and signal transduction. beta-TrCP function is essential for the induction of nuclear factor kappaB transcriptional activities, which play a key role in proliferation and survival of cancer cells and are often constitutively...

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PMID: 15753389
DOI: 10.1158/0008-5472.CAN-04-2597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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