Article
Convergent evolution of zoonotic Brucella species toward the selective use of the pentose phosphate pathway.
Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2020
Machelart Arnaud, Willemart Kevin, Zúñiga-Ripa Amaia, Godard Thibault, Plovier Hubert, Wittmann Christoph, Moriyón Ignacio, De Bolle Xavier, Van Schaftingen Emile, Letesson Jean-Jacques, Barbier Thibault
Abstract excerpt
Mechanistic understanding of the factors that govern host tropism remains incompletely understood for most pathogens. Brucella species, which are capable of infecting a wide range of hosts, offer a useful avenue to address this question. We hypothesized that metabolic fine-tuning to intrahost niches is likely an underappreciated axis underlying pathogens' ability to infect new hosts and tropism. In this work, we...
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