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Article

Detection of RAS mutations in circulating tumor cells: applications in colorectal cancer and prospects.

Annales de biologie clinique - 1 Dec 2017

Denis Jérôme Alexandre, Lacorte Jean-Marc

Abstract excerpt

The somatic mutations in the RAS genes (KRAS and NRAS) are widely associated with non-response to immunotherapies targeting the epidermal growth factor receptor in metastatic colorectal cancer. The detection of these mutations is carried out from tissue biopsies and become mandatory to prescribe these treatments. Nethertheless, this analysis is not possible in about 25% of cases and the development of alternative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29192596
DOI: 10.1684/abc.2017.1304

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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